Infliximab versus Cyclosporine Treatment for Severe Corticosteroid-Refractory Ulcerative Colitis: A Korean, Retrospective, Single Center Study.
- Author:
Eun Hye KIM
1
;
Duk Hwan KIM
;
Soo Jung PARK
;
Sung Pil HONG
;
Tae Il KIM
;
Won Ho KIM
;
Jae Hee CHEON
Author Information
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords: Colitis, ulcerative; Cyclosporine; Infliximab
- MeSH: Adrenal Cortex Hormones/therapeutic use; Adult; Aged; Azathioprine/therapeutic use; Colectomy/statistics & numerical data; Colitis, Ulcerative/*drug therapy; Cyclosporine/*therapeutic use; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents/*therapeutic use; Infliximab/*therapeutic use; Male; Middle Aged; Proportional Hazards Models; Republic of Korea; Retrospective Studies; Salvage Therapy/*methods; Treatment Outcome; Young Adult
- From:Gut and Liver 2015;9(5):601-606
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: In patients with corticosteroid-refractory ulcerative colitis (UC), cyclosporine or infliximab may be added to the treatment regimen to induce remission. Here, we aimed to compare the efficacy of cyclosporine and infliximab. METHODS: Between January 1995 and May 2012, the medical records of 43 patients with corticosteroid-refractory UC who received either infliximab or cyclosporine as a rescue therapy at a tertiary care hospital in Korea were reviewed. RESULTS: Among the 43 patients, 10 underwent rescue therapy with cyclosporine and the remaining 33 patients received infliximab. A follow-up of 12 months was completed for all patients. The colectomy rate at 12 months was 30% and 3% in the cyclosporine and the infliximab groups, respectively (p=0.034). However, the Cox proportional hazard model indicated that the treatment of rescue therapy was not an independent associate factor for preventing colectomy (p=0.164). In the subgroup analysis, infliximab with azathioprine was superior to cyclosporine for preventing colectomy (hazard ratio of infliximab with azathioprine compared with cyclosporine only, 0.073; 95% confidence interval, 0.008 to 0.629). CONCLUSIONS: No difference between infliximab and cyclosporine with respect to preventing colectomy was noted. However, infliximab with azathioprine may be more effective than cyclosporine alone for preventing colectomy.
