Angiocentric T cell Lymphoma associated with Epstein-Barr Virus.
10.5021/ad.1999.11.4.292
- Author:
Ji Yong PARK
;
Nack In KIM
- Publication Type:Original Article
- Keywords:
Angiocentric T cell lymphoma;
EBV
- MeSH:
Biopsy;
Blood Vessels;
Cyclophosphamide;
Doxorubicin;
Drug Therapy, Combination;
Genome;
Herpesvirus 4, Human*;
Humans;
In Situ Hybridization;
Lymphocytes;
Lymphoma, T-Cell*;
Lymphoma, T-Cell, Peripheral;
Prednisolone;
RNA;
Skin;
Vincristine
- From:Annals of Dermatology
1999;11(4):292-296
- CountryRepublic of Korea
- Language:English
-
Abstract:
Angiocentric T-cell lymphomas have been described as a distinctive clinicopathologic entity in the spectrum of peripheral T-cell lymphomas, with a prominent invasion of blood vessels by lymphomatous cells. In these conditions, the presence of Epstein-Barr virus (EBV) genomes has been demonstrated, suggesting that EBV might play a major role in their cause. Herein, we report a case of cutaneous angiocentric T cell lymphoma associated with the EBV. The patient was diagnosed with nasal angiocentric T cell lymphoma 5 months ago, and treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) combination chemotherapy. After three cycles of CHOP, skin lesions developed. A skin biopsy specimen showed an angiocentric and angioinvasive infiltrate containing some atypical lymphocytes. EBV encoded RNA (EBER) was demonstrated in lesional skin by in situ hybridization.
