Transient Bullous Dermolysis of the Newborn.
- Author:
In Kyung JEON
1
;
Soo Chan KIM
Author Information
1. Department of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea. kimsc@yuhs.ac
- Publication Type:Case Report
- Keywords:
Dystrophic epidermolysis bullosa;
Transient bullous dermolysis of the newborn
- MeSH:
Blister;
Collagen;
Collagen Type VII;
Electrons;
Endoplasmic Reticulum, Rough;
Epidermolysis Bullosa Dystrophica;
Fluorescent Antibody Technique;
Humans;
Infant, Newborn;
Microscopy, Electron;
Parturition;
Skin
- From:Korean Journal of Dermatology
2013;51(1):40-44
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Transient bullous dermolysis of the newborn (TBDN) is a rare subtype of the dystrophic epidermolysis bullosa characterized by blistering at birth which improves spontaneously during early life. Electron microscopy showed sublamina densa separation with dilated rough endoplasmic reticulum and electron dense inclusions. Immunofluorescence mapping using anti-type VII collagen antibody showed widespread intraepidermal type VII collagens which are a characteristic finding of TBDN. Here, we report two cases of TBDN presenting typical clinical manifestations, electron microscopy findings, and immunofluorescence mapping results. The skin lesions of both patients healed spontaneously 2~3 months later.
