Association of Apolipoprotein E Genotypes with Late-onset Alzheimer's Disease in Korea.
- Author:
Yong S LEE
1
;
Duk L NA
;
Jong W KIM
Author Information
1. Departutent of Neurology, Samsung Medical Center.
- Publication Type:Original Article
- MeSH:
Alleles;
Alzheimer Disease*;
Apolipoprotein E4;
Apolipoproteins E;
Apolipoproteins*;
Dementia;
Diagnosis, Differential;
Gene Frequency;
Genotype*;
Humans;
Korea*;
Polymerase Chain Reaction;
Risk Factors
- From:Journal of the Korean Neurological Association
1996;14(2):538-542
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Apolipoprotein E-epsilon4(APOE4) is recently known as a susceptibility gene or risk factor associated with late-onset Alzheimer's disease (AD). Association between APOE4 and probable AD was determined in Korean population. Twenty patients met the NINCDS-ADRDA probable AD criteria (M:F=7:13, Mean age: 70.1 yr)were compared with 146 controls without dementia (M:F=83:63, Mean age:63.6 yr). APOE genotype was determined by polymerase chain reaction and allele specific hybridization technique. APOE4 allele frequency (0.33 vs. 0.11, p<.01) and proportion of carriers with APOE4(60% vs. 19%, p<.01) were significantly increased in patient group. APOE4 genotype is also associated with late-onset sporadic AD in Korean, and APOE genotyping may be useful for differential diagnosis of AD for patients with dementia.
