Histopathological and immunohistochemical studies of polymorphic reticulosis.
10.3349/ymj.1990.31.3.212
- Author:
Young Nyun PARK
1
;
Woo Ick YANG
;
Kwang Gil LEE
;
In Joon CHOI
Author Information
1. Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Lethal midline granuloma;
polymorphic reticulosis;
peripheral T-cell lymphoma
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Antigens, Differentiation, T-Lymphocyte/*analysis;
Antigens, Neoplasm/analysis;
Blood Sedimentation;
Comparative Study;
Female;
Head and Neck Neoplasms/chemistry/*pathology;
Human;
Lymphoma, T-Cell/*pathology;
Male;
Middle Age;
Nasopharyngeal Neoplasms/chemistry/pathology;
Neoplasm Proteins/analysis;
Reticuloendotheliosis/metabolism/*pathology;
Support, Non-U.S. Gov't;
Tumor Markers, Biological/analysis
- From:Yonsei Medical Journal
1990;31(3):212-218
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study reviewed 65 cases of polymorphic reticulosis (PR) with respect to clinical and histopathologic bases, and immunohistochemical studies were done using MT1 and UCHL as T-cell markers, MB2 as a B-cell marker and alpha-1-antichymotrypsin as a histiocytic marker. The results obtained were as follows: 1. The male to female ratio was 2.4:1 and the mean age of patients was 44.5 years. The sites involved primarily were the nasal cavity, tonsil and pharynx and about one-fourth of the total cases showed extensive involvement of two anatomical sites at initial presentation. 2. Almost all cases showed characteristic histologic features similar to those of peripheral T-cell lymphoma and showed positive reaction to the T-cell marker. The above immunohistochemical findings suggest strongly that quite a significant portion of PR is in fact T-cell lymphoma.
