Unusual Cutaneous Manifestations of Connective Tissue Diseases: IV . Bullous Eruptions in Systemic Lupus Erythematosus.
- Author:
Chang Woo LEE
;
Ki Bum PARK
;
Hwan HERR
;
Hee Chul EUN
;
Jail Il YOUN
;
Yoo Shin LEE
- Publication Type:Case Report
- Keywords:
Lupus erythematosus;
Systemic;
Bullous;
Circulating anti - basement membrane zone antibodies
- MeSH:
Basement Membrane;
Blister;
Connective Tissue Diseases*;
Connective Tissue*;
Dapsone;
Diagnosis;
Epidermis;
Female;
Forearm;
Humans;
Immunoglobulin G;
Lupus Erythematosus, Systemic*;
Membranes;
Neck;
Neutrophils;
Skin;
Upper Extremity
- From:Korean Journal of Dermatology
1986;24(3):406-411
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The cases of bullous eruption of systemic lupus erythematosus in this study were two females. They were the age of 18 and 15. Both of them met ARA criteria for a diagnosis of SLE, and the eruptions developed long after the diagnosis. In both cases bullae were presented on the face, neck and upper extremities. Administration of dapsone showed complete clearing of lesions within several days. Routine histology of the lesion showed subepidermal blisters, an intact epidermis, ancl neutrophilic microabscess in dermal papillae. Direct munofluorescence of perilesional and normal forearm skin showed coarse linear pattern of immune deposits at the basement membrane zone in both cases. Circulating anti-basement membrane zone IgG auto-antibodies were detected at a titer of 1: 32 and 1: 16 in each case on NaC1 separated skin substrates.
