Serum Levels of Growth Factors in Alcohol-dependent Patients according to Comorbid Depressive Symptoms.
- Author:
Changwoo HAN
1
;
Donghyun AHN
;
Woong HAHM
;
Junghyun NAM
;
Yongchon PARK
;
Seulgi LIM
;
Dai Jin KIM
Author Information
- Publication Type:Original Article
- Keywords: Alcohol dependence; Depression; Growth factor; Insulin-like growth factor-1
- MeSH: Alcoholism; Biomarkers; Brain-Derived Neurotrophic Factor; Demography; Depression*; Drinking; Enzyme-Linked Immunosorbent Assay; Humans; Inpatients; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins*; Nerve Growth Factor
- From:Clinical Psychopharmacology and Neuroscience 2016;14(1):43-48
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: This study aims to reveal the relationship of depression with growth factors such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and insulin-like growth factor-1 (IGF-1) in inpatients diagnosed with alcohol dependence, and to identify candidate growth factors as biological markers to indicate the comorbid of alcohol dependence and depression. METHODS: This study examined demographic factors in 45 alcohol-dependent patients. The ADS (Korean version of the Alcohol Dependence Scale) and BDI (Korean version of Beck's Depression Inventory) were used. BDNF, NGF, and IGF-1 were measured through ELISA. RESULTS: The average drinking quantity and the ADS score were significantly more severe in alcohol-dependent patients with depression than in those without depression. Linearly comparing BDNF, NGF, and IGF-1 with BDI values, IGF-1 was the growth factor significantly correlated with BDI scores. BDI scores were significantly correlated with ADS scores. IGF-1 was significantly higher in alcohol-dependent patients with depression. Alcohol-dependent patients with depression had greater alcohol use and more severe ADS scores. BDNF and NGF showed no significant difference between alcohol-dependent patients with and without depression, but IGF-1 was significantly higher in those with than in those without depression. CONCLUSION: IGF-1 was found to be associated with depression in alcohol-dependent patients, suggesting that IGF-1 in alcohol-dependent patients could be an important biomarker to indicate whether alcohol-dependence is accompanied by depression.
