Metformin for Lithium-induced Weight Gain: A Case Report.
10.9758/cpn.2016.14.1.101
- Author:
Samir Kumar PRAHARAJ
1
Author Information
1. Department of Psychiatry, Kasturba Medical College, Manipal, Karnataka, India. samirpsyche@yahoo.co.in
- Publication Type:Case Report
- Keywords:
Lithium;
Metformin;
Weight gain;
Antimanic
- MeSH:
Adipose Tissue;
Bipolar Disorder;
Circadian Rhythm;
Eating;
Humans;
Insulin Resistance;
Leptin;
Lithium;
Liver;
Male;
Metformin*;
Muscle, Skeletal;
Physiology;
Weight Gain*
- From:Clinical Psychopharmacology and Neuroscience
2016;14(1):101-103
- CountryRepublic of Korea
- Language:English
-
Abstract:
Lithium is the first line treatment for maintenance treatment of bipolar disorder. Among the long term adverse effects, weight gain is likely to affect a subset of patients. There is no specific guideline for the treatment of lithium-induced weight gain. We report a young male with bipolar disorder who had significant weight gain with lithium (25 kg), which responded to metformin treatment at 500 mg twice daily. The proposed mechanism of weight lowering effect of metformin includes changes in hypo-thalamic physiology, including leptin and insulin sensitivity, as well as circadian rhythm changes affecting food intake, regulation of fat oxidation and storage in liver, skeletal muscle, and adipose tissue.
