Study of Serum IgE Level and RAST (D. pteronyssinus, D. farinae, Egg White and Cow Milk) at Preschool Children.
- Author:
Dae Hyun LIM
1
;
Jung Hee KIM
;
Byong Kwan SON
Author Information
1. Department of Pediatrics, College of Medicine, Inha University, Inchon, Korea.
- Publication Type:Original Article
- Keywords:
Serum IgE;
RAST (Dp, Df, egg, milk);
Preschool children
- MeSH:
Antibodies;
Asthma;
Child;
Child, Preschool*;
Dermatitis, Atopic;
Diagnosis;
Egg White*;
Female;
Food Hypersensitivity;
Humans;
Immunoglobulin E*;
Incheon;
Interviews as Topic;
Male;
Mass Screening;
Microcomputers;
Milk;
Milk Hypersensitivity;
Ovum*;
Parents;
Rhinitis;
Statistics as Topic
- From:Pediatric Allergy and Respiratory Disease
1999;9(4):385-395
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The tests of Serum IgE and allergen specific antibodies are important for screening and diagnosis of allergic disease. This study was conducted find out the distributions of allergic diseases, level of IgE, and usual allergen specific antibodies in healthy well-being preschool childrenin Inchon city. METHODS: We gained the level of serum IgE and RAST (radioallergosorbent test : D. pteronyssinus, D. farinae, Egg white and Cow milk) for 274 (Male 130, Female 144) preschool children in Inchon city during January through June in 1997. The history of allergic diseases (allergic asthma, allergic rhinitis, atopic dermatitis, food allergy and urticaria) was taken by each children's parent over telephone interviews. The personal computer SAS program was used for data analysis. RESULTS: 1) The 274 preschoolers (female 144, male 130 F:M=1:0.9) were composed of 74 (female 44, male 30) 3 year-old, 99 (female 52, male 47) 4 year-old, and 101 (female 48, male 53) 5 year-old children. 2) 30.1% of the children were with history of allergic diseases. 3) The mean and standard deviation of serum IgE levels were 215.8+/-171.0 IU/mL with a history of allergic diseases and 60.4+/-73.2 IU/mL without a history of allergic diseases for 3 year-old; 237.0+/-233.5 IU/mL and 48.5+/-74.4 IU/mL for 4 year-old; and 223.6+/-247.5 IU/ml and 45.2+/-41.9 IU/mL for 5 year-old children (P<0.001), respectively. 4) The rate of positive RAST (D. pteronyssinus, Dp) was 66.7% with a history of allergic diseases and 2.6% without a history of allergic diseases for 3 year-old girls, and 41.7% and 5.6% for 3 year-old boys; 58.3% and 2.5% for 4 year-old girls, and 53.8% and 2.9% for 4 year-old boys; and 61.1% and 3.3% for 5 year-old girls, and 54.5% and 0.0% for 5 year-old boys (P<0.001), respectively. 5) The rate of positive RAST (D. farinae, Df) was 66.7% with a history of allergic diseases and 0.0% without a history of allergic diseases for 3 year-old girls, and 16.7% and 0.0% for 3 year-old boys; 50.0% and 0.0% for 4 year-old girls, and 46.2% and 5.9%, for 4 year-old boys; and 55.6% and 3.3% for 5 year-old girls, and 54.5% and 0.0% for 5 year-old boys (P<0.001), respectively. 6) The rate of positive RAST (Egg white, F1) was 66.7% with a history of allergic diseases and 21.1% without a history of allergic diseases for 3 year-old girls, and 66.7% and 38.9% for 3 year-old boys; 75.0% and 15.0% for 4 year-old girls, and 46.2% and 5.9% for 4 year-old boys; and 38.9% and 13.3% for 5 year-old girls, and 50.0% and 19.4% for 5 year-old boys (P<0.001), respectovely. 7) The rate of positive RAST (Cow milk F2) was 0.0% for 3, 4 and 5 year-old and boys both with and without a history of allergic diseases. CONCLUSION: We conclude that serum IgE level and RAST (Dp, Df, F1) are important screening methods for allergic disease of preschool children, and milk allergy is little over 3 year-old children in Inchon. Further studies will be needed.
