Identification of Dioscorea Batatas (Sanyak) Allergen as an Inhalant and Oral Allergen.
10.3346/jkms.2008.23.1.72
- Author:
Gyu Young HUR
1
;
Han Jung PARK
;
Hyoun Ah KIM
;
Young Min YE
;
Hae Sim PARK
Author Information
1. Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea. hspark@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Allergen;
Dioscorea batatas;
Sanyak;
Food Hypersensitivity;
Inhalant Allergy
- MeSH:
Administration, Inhalation;
Administration, Oral;
Adult;
Allergens/*immunology;
Amino Acid Sequence;
Dioscorea/*immunology;
Electrophoresis, Gel, Two-Dimensional;
Enzyme-Linked Immunosorbent Assay;
Female;
Humans;
Immunoblotting;
Immunoglobulin E/blood;
Immunoglobulin G/blood;
Molecular Sequence Data
- From:Journal of Korean Medical Science
2008;23(1):72-76
- CountryRepublic of Korea
- Language:English
-
Abstract:
Dioscorea batatas is widely used in Asia as a herbal medicine or food product with potential health benefits. There have been several reports of occupational asthma caused by inhalation of D. batatas dust. However, there has been no report of systemic allergic reactions after oral administration of D. batatas. Two patients with D. batatas allergy were enrolled. One had experienced severe urticaria and angioedema after indigestion, and the other had been exposed to D. batatas dust and was diagnosed as having occupational asthma. Both patients had high serum-specific IgE and IgG4 antibodies to D. batatas. And IgE immunoblot demonstrated that both sera bound to a 27-kDa protein with an IgE-binding motif, which was revealed by 2-D-electrophoresis to have the sequence Asn-Val-Glu-Asp-Glu-Phe-Ser-X-Ile- Glu-Gly-Asn-Pro-X-X-Pro-Glu-Asn-X-Gly (pI 6.40, 6.04). In conclusion, discorin from D. batatas (DB3S) was identified as the major allergen of D. batatas in patients sensitized via an oral or inhalant route.
