A Case of Collapsing Glomerulopathy in Renal Allograft.
- Author:
Ji Hwan KIM
1
;
Jung IM JUNG
;
Ju Yeon NAM
;
Jong In KIM
;
Joong Kyung KIM
;
Yeon Soon JUNG
;
Hark RIM
;
Min Jung JUNG
Author Information
1. Department of Internal Medicine, Bong Seng Hospital, Busan, Korea. kidney119@hotmail.com
- Publication Type:Case Report
- Keywords:
Focal segmental glomerulosclerosis (FSGS);
Nephrotic
- MeSH:
AIDS-Associated Nephropathy;
Biopsy;
Capillaries;
Epithelial Cells;
Glomerulosclerosis, Focal Segmental;
HIV Infections;
Humans;
Kidney;
Kidney Failure, Chronic;
Male;
Methylprednisolone;
Nephrotic Syndrome;
Transplantation, Homologous;
Transplants
- From:Korean Journal of Nephrology
2008;27(1):162-165
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Collapsing glomeruopathy (CG) is a clinicopathologic variant of focal segmental glomerulosclerosis (FSGS) and is characterized by severe nephrotic syndrome, rapid progression to end stage renal disease, and features of visceral epithelial cell injury and glomerular capillary collapse. Such characteristics closely resemble those of HIV associated nephropathy. The frequency of CG has increased over the last decade. The cause of CG is unknown. The lesion has rarely been described in renal allografts with features similar to CG in native kidney. We recently identified allograft CG in a 44 year-old male patient who underwent biopsy for graft dysfunction after autodermic graft. The biopsy showed typical characteristics of CG. Serologically, the patient had no evidence of HIV infection. The renal function was not restored to normal in spite of methylprednisolone pulsing therapy. Now he is on conservative treatment with a functioning graft.
