Two Cases of Antisynthetase Syndrome Combined with Mechanic's Hand.
- Author:
Chae Kyu KIM
1
;
Dae Hyun YOO
;
Yong Ho SONG
;
Ja Hun JUNG
;
Sung Min NOH
;
Young Bae OH
;
Jae Bum JUN
;
Sung Soo JUNG
;
In Hong LEE
;
Sang Cheol BAE
;
Seong Yoon KIM
Author Information
1. The Hospital for Rheumatic Diseases, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Antisynthetase syndrome;
Myositis;
Aminoacy1-tRNA synthetase
- MeSH:
Arthritis;
Autoantibodies;
Fever;
Hand*;
Humans;
Ligases;
Lung Diseases;
Myositis
- From:The Journal of the Korean Rheumatism Association
1999;6(2):178-184
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The antisynthetase syndrome is characterized by inflammatory myositis associated with intersititial lung disease (ILD), polyarthritis, mechanic's hand, and Raynaud's phenomenon, and usually with fever. The patients with these conditions have autoantibodies to aminoacy1-tRNA synthetases (histidy1-, threony1-, alany1-, isoleucy1-, and glycy1-tRNA synthetase) ; the most common is anti-histidy1-tRNA sythetase (anti Jo-1), present in 20% of myositis patients in Western countries. However, the mechanisms of production of autoantibodies to aminoacy1-tRNA synthetases are not understood. Several hypotheses about the relationship of anti-aminoacy1-tRNA synthetases with inflammatory myositis have been reported. The poor prognostic outcome for the antisynthetase patients are related to ILD. We experienced two cases of antisynthetase syndrome which have characterized by the clinical manifestations, and report these cases with a review of the literatures.
