Experimental study on the periodontal regenerative capacity of moldable synthetic peptide domain gel in degree III furcation defect of beagles.
10.5051/jkape.2008.38.4.621
- Author:
Jeong Beom KIM
1
;
Yoon Jeong PARK
;
Sang Cheol LEE
;
Tae Il KIM
;
Yang Jo SEOL
;
Yong Moo LEE
;
Young GU
;
In Chul RHYU
;
Soo Boo HAN
;
Chong Pyoung CHUNG
Author Information
1. Department of Periodontology, Schoolof Dentistry, Seoul National University, Korea. ccpperio@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Collagen binding domain;
Peptide domain;
Regeneration;
Osteopontin
- MeSH:
Animals;
Bicuspid;
Collagen;
Dental Cementum;
Furcation Defects;
Mandible;
Osteogenesis;
Osteopontin;
Protein Structure, Tertiary;
Regeneration
- From:The Journal of the Korean Academy of Periodontology
2008;38(4):621-628
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Osteopontin is one of the major non-collagenous protein of hard tissue. Use of peptide domain of biologically active protein has some advantages. The objective of this experimental study is evaluation of periodontal regenerative potency of synthetic peptide gel which containing collagen binding domain of osteopontin in the degree III periodontal defect of beagle dogs. MATERIAL AND METHODS: Experimental degree III furcation defect was made in the mandibular third and fourth premolar of beagles. Regenerative material was applied during flap operation. 8 weeks after regenerative surgery, all animals were sacrificed and histomorphometric measurement was performed to calculate the linear percentage of the new cementum formation and the volume percentage of new bone formation. RESULT: The linear percent of new cementum formation was 41.6% at control group and 67.1% at test group and there was statistically significant difference. The volume percent of new bone formation was 52.1% at control group and 58.9% at test group. CONCLUSION: As the results of present experiment, synthetic peptide gel containing collagen binding domain of osteopontin significantly increase new bone and cementum formation in the degree III furcation defect of canine mandible.
