Is There Any Relationship between the Chronicity of Chronic Anal Fissure and Endothelin-1?.
10.3393/jksc.2011.27.5.237
- Author:
Cheong Ho LIM
1
;
Hyeon Keun SHIN
;
Wook Ho KANG
;
Seung Kyu JEONG
;
Hyung Kyu YANG
Author Information
1. Department of Coloproctology, Yang Hospital, Seoul, Korea. chlim3164@naver.com
- Publication Type:Original Article
- Keywords:
Chronic anal fissure;
Endothelin-1;
Chronicity;
Ischemia;
Endothelium
- MeSH:
Endothelin-1;
Endothelium;
Female;
Fissure in Ano;
Hemorrhoids;
Humans;
Ischemia;
Male
- From:Journal of the Korean Society of Coloproctology
2011;27(5):237-240
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Many kinds of substances are produced on vascular endothelial activation. The aim of this study is to confirm an increase in Endothelin-1 (ET-1), the most potent vasoconstrictor, which is produced by endothelial activation, in patients with chronic anal fissure and to infer the relationship between ET-1 and anal fissure chronicity. METHODS: The study groups are divided into three different groups with 30 subjects each. Group 1 is comprised of healthy volunteers, group 2 of chronic anal fissure patients, and Group 3 of patients with higher than 3rd degree hemorrhoids. Blood samples were taken to measure the ET-1 levels in subject's serum and to compare the results with those for the control groups. RESULTS: Among the 90 subjects, 38 were male, and 52 were female. The average age was 36.8. The average ET-1 level marked 1.47 +/- 0.78 pg/mL for male subjects and 1.16 +/- 0.47 pg/mL for female subjects (P = 0.02). The average ET-1 level in the patient groups is as follow: 1.21 +/- 0.44 pg/mL in group 1, 1.46 +/- 0.83 pg/mL in group 2, and 1.20 +/- 0.56 pg/mL in group 3 (P = 0.14). CONCLUSION: Group 2, the chronic anal fissure patient group, showed a higher ET-1 level than groups 1 and 3, the control group and the hemorrhoid patient group, but this difference had no statistical significance.