Oxaliplatin-induced Pulmonary Fibrosis: Two Case Reports.
10.3393/jksc.2011.27.5.266
- Author:
Chun Geun RYU
1
;
Eun Joo JUNG
;
Gangmi KIM
;
Su Ran KIM
;
Dae Yong HWANG
Author Information
1. Department of Surgery, Colorectal Cancer Center, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea. hwangcrc@kuh.ac.kr
- Publication Type:Case Report
- Keywords:
Oxaliplatin;
Toxicity;
Pulmonary fibrosis
- MeSH:
Antineoplastic Combined Chemotherapy Protocols;
Colorectal Neoplasms;
Diarrhea;
Fluorouracil;
Humans;
Leucovorin;
Neutropenia;
Organoplatinum Compounds;
Peripheral Nervous System Diseases;
Pulmonary Fibrosis;
Vomiting
- From:Journal of the Korean Society of Coloproctology
2011;27(5):266-269
- CountryRepublic of Korea
- Language:English
-
Abstract:
Oxaliplatin with infusional 5-fluorouracil plus leucovorin (FOLFOX regimen) is the one of the standard chemotherapy regimens for treating a colorectal carcinoma. The most common side effects include neutropenia, diarrhea, vomiting and peripheral neuropathy, and these are moderate and manageable. However, pulmonary toxicity is rarely reported to be associated with the FOLFOX regimen. Moreover, there is no established guideline for the management of this side effect. Here, along with a literature review, we report two cases of rapidly developing pulmonary fibrosis related to the use of the FOLFOX regimen in patients with colorectal carcinomas.
