A case of hepatoblastoma misdiagnosed as combined hepatocellular carcinoma and cholangiocarcinoma in an adult.
10.3350/cmh.2015.21.3.300
- Author:
Keun Woo PARK
1
;
Chang Jin SEO
;
Dae Young YUN
;
Min Keun KIM
;
Byung Seok KIM
;
Young Seok HAN
;
Hoon Kyu OH
;
Chang Hyeong LEE
Author Information
1. Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. chlee1@cu.ac.kr
- Publication Type:Case Reports
- Keywords:
Hepatoblastoma;
Surgery;
Chemotherapy
- MeSH:
Adult;
Carcinoma, Hepatocellular/pathology;
Cholangiocarcinoma/pathology;
Cisplatin/therapeutic use;
Diagnostic Errors;
Doxorubicin/therapeutic use;
Drug Therapy, Combination;
Female;
Fluorouracil/therapeutic use;
Hepatitis B, Chronic/complications/diagnosis;
Hepatoblastoma/drug therapy/*pathology/radiography;
Humans;
Liver Neoplasms/drug therapy/*pathology/radiography;
Tomography, X-Ray Computed;
Vincristine/therapeutic use
- From:Clinical and Molecular Hepatology
2015;21(3):300-308
- CountryRepublic of Korea
- Language:English
-
Abstract:
Hepatoblastoma usually occurs in children under the age of 2 years, with very few cases reported in adults. We experienced a case of adult hepatoblastoma in a 36-year-old female with chronic hepatitis B . She had experienced sudden onset abdominal pain. Her serum alpha-fetoprotein level was markedly elevated, and abdominal CT showed a 9-cm mass with internal hemorrhage in the right hepatic lobe with hemoperitoneum, so an emergency hepatic central bisectionectomy was performed. The initial histologic examination revealed that the mass mimicked combined hepatocellular carcinoma and cholangiocarcinoma with spindle-cell metaplasia of the cholangiocarcinoma element. Follow-up abdominal CT performed 3 months later showed a 5.5-cm metastatic mass in the left subphrenic area. Laparoscopic splenectomy with mass excision was performed, and hepatoblastoma was confirmed histologically. A histologic re-examination of previously obtained surgical specimens also confirmed the presence of hepatoblastoma. Metastatic hepatoblastoma was found at multiple sites of the abdomen during follow-up, and so chemotherapy with cisplatin, 5-fluorouracil (5-FU), and vincristine was applied, followed by carboplatin and doxorubicin . Despite surgery and postoperative chemotherapy, she died 12 months after symptom onset.
