Genetic studies of allergic disease and their clinical implications.
- Author:
Seung Hyun KIM
1
;
Hae Sim PARK
Author Information
1. Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea.
- Publication Type:Review
- Keywords:
Allergic disease;
Genetic study;
Positional cloning;
Association study
- MeSH:
Ethnic Groups;
Humans
- From:Korean Journal of Medicine
2009;76(4):416-424
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Allergic disease is a complex disorder in which the interaction between environmental and genetic effects may modify both the susceptibility to and severity of the disease. Over the last few years, our understanding of the genetic basis of allergic diseases has improved markedly, which has led to the identification of several chromosome regions and loci showing linkage to allergic disease. As another approach, association studies between candidate gene polymorphisms and allergic diseases have been conducted in many areas and replicated in different ethnic groups. These approaches need to be followed by validation processes to confirm their functional relevance in the pathophysiology of allergic disease. This review updates genetic studies of and recent findings in, allergic disease.
