Clinical and Biochemical Parameters of Nutrition to Predict Hepatic Encephalopathy in Cirrhotic Patients.
- Author:
Hyung Keun KIM
1
;
Hyun Jong OH
;
Sun Woo NAM
;
Jong Young CHOI
;
Se Hyun CHO
;
Seung Kyu YOON
;
Jun Yeol HAN
;
Jin Mo YANG
;
Nam Ik HAN
;
Byung Min AHN
;
Sang Wook CHOI
;
Jae Kwang KIM
;
Young Suk LEE
;
Kyu Won CHUNG
;
Hee Sik SUN
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. kwchung@catholic.ac.kr
- Publication Type:English Abstract ; Original Article
- Keywords:
Hepatic encephalopathy;
Nutritional assessment;
Anthropometry;
Leptin
- MeSH:
Aged;
Anthropometry;
Biological Markers/*blood;
Female;
Hepatic Encephalopathy/blood/diagnosis/*etiology;
Humans;
Insulin-Like Growth Factor I/analysis;
Leptin/blood;
Liver Cirrhosis/blood/*complications;
Male;
Middle Aged;
*Nutritional Status;
Transferrin/analysis
- From:The Korean Journal of Gastroenterology
2006;47(1):44-51
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Protein-calorie malnutrition is a common complication in cirrhosis. Protein restriction for the treatment of hepatic encephalopathy (HE) may cause disease progression and poor prognosis. Therefore, we evaluated important clinical parameters for nutritional state in cirrhotic patients with or without HE to predict the development of HE. METHODS: Twenty-two cirrhotic patients were divided into two groups; group A-13 patients without HE and group B-9 patients with HE. Clinical and biochemical parameters, serum proteins {serum albumin, insulin-like growth factor-1 (IGF-1), transferrin, leptin, etc}, immunologic parameters and anthropometry were measured. RESULTS: Child-Pugh score and Model for End-stage Liver Disease (MELD) scale were higher in group B (p<0.01). After correction of various factors affecting nutritional assessment, especially of Child-Pugh score and MELD scale, leptin was higher in group B (p<0.05). There was no difference in anthropometric measurements. Transferrin correlated inversely with MELD scale in group A (p<0.01). IGF-1 correlated inversely with total lymphocyte count in group B (p<0.05). Leptin correlated with Child-Pugh scores, total lymphocyte count and mid-arm muscle cirumference in group A (p<0.05, p<0.05 and p<0.05, respectively), and correlated inversely with CD8 in group B (p<0.05). CONCLUSIONS: Leptin level is higher in patients with HE, and further studies for parameters of nutrition to predict HE in many cirrhotic patients will be needed.
