Antihypertensive Treatment of Acute Intracerebral Hemorrhage by Intravenous Nicardipine Hydrochloride: Prospective Multi-Center Study.
10.3346/jkms.2012.27.9.1085
- Author:
Sung Kyun HWANG
1
;
Jong Soo KIM
;
Jung Hee KIM
;
Chang Ki HONG
;
Kook Hee YANG
Author Information
1. Department of Neurosurgery, Ewha Womans University College of Medicine, Seoul, Korea. nshsg@ewha.ac.kr
- Publication Type:Original Article ; Clinical Trial ; Multicenter Study
- Keywords:
Intracerebral Hemorrhage;
Hypertension;
Nicardipine Hydrochloride;
Prospective Studies
- MeSH:
Acute Disease;
Adult;
Aged;
Aged, 80 and over;
Antihypertensive Agents/adverse effects/*therapeutic use;
Blood Pressure;
Cerebral Hemorrhage/*drug therapy;
Cohort Studies;
Female;
Follow-Up Studies;
Glasgow Coma Scale;
Hematoma/etiology;
Humans;
Injections, Intravenous;
Male;
Middle Aged;
Nicardipine/adverse effects/*therapeutic use;
Prospective Studies;
Tomography, X-Ray Computed;
Treatment Outcome
- From:Journal of Korean Medical Science
2012;27(9):1085-1090
- CountryRepublic of Korea
- Language:English
-
Abstract:
The authors performed a multicenter prospective study to evaluate the feasibility and safety of intravenous nicardipine hydrochloride for acute hypertension in patients with intracerebral hemorrhage (ICH). This study included 88 patients (mean age: 58.3 yr, range 26-87 yr) with ICH and acute hypertension in 5 medical centers between August 2008 and November 2010, who were treated using intravenous nicardipine. Administration of nicardipine resulted in a decrease from mean systolic blood pressure (BP) (175.4 +/- 33.7 mmHg) and diastolic BP (100.8 +/- 22 mmHg) at admission to mean systolic BP (127.4 +/- 16.7 mmHg) and diastolic BP (67.2 +/- 12.9 mmHg) in 6 hr after infusion (P < 0.001, mixed-effect linear models). Among patients who underwent follow-up by computed tomography, hematoma expansion at 24 hr (more than 33% increase in hematoma size at 24 hr) was observed in 3 (3.4%) of 88 patients. Neurological deterioration (defined as a decrease in initial Glasgow coma scale > or = 2) was observed in 2 (2.2%) of 88 patients during the treatment. Aggressive nicardipine treatment of acute hypertension in patients with ICH can be safe and effective with a low rate of neurological deterioration and hematoma expansion.
