Ceftiaxone-Induced Neurotoxicity: Case Report, Pharmacokinetic Considerations, and Literature Review.
10.3346/jkms.2012.27.9.1120
- Author:
Ki Bae KIM
1
;
Sun Moon KIM
;
Woori PARK
;
Ji Seon KIM
;
Soon Kil KWON
;
Hye Young KIM
Author Information
1. Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea. uptoyousm@gmail.com
- Publication Type:Case Reports
- Keywords:
Ceftriaxone;
Cephalosporins;
Chronic Kidney Failure;
Seizures
- MeSH:
Aged;
Anti-Bacterial Agents/*adverse effects/therapeutic use;
Anticoagulants/therapeutic use;
Ceftriaxone/*adverse effects/therapeutic use;
Electroencephalography;
Female;
Humans;
Nervous System Diseases/*etiology;
Renal Dialysis;
Renal Insufficiency, Chronic/pathology;
Seizures/etiology;
Thrombosis/diagnosis/drug therapy;
Tomography, X-Ray Computed;
Urinalysis;
Urinary Tract Infections/diagnosis/drug therapy
- From:Journal of Korean Medical Science
2012;27(9):1120-1123
- CountryRepublic of Korea
- Language:English
-
Abstract:
Ceftriaxone is widely used in patients for the treatment of serious gram-negative infections. Ceftriaxone can induce some potential side effects, including neurotoxicity, however, nonconvulsive status epilepticus has rarely been reported. We report a case of acute reversible neurotoxicity associated with ceftriaxone. A 65-yr-old woman with chronic kidney disease developed altered consciousness during ceftriaxone treatment for urinary tract infection. The electroencephalogram demonstrated continuous bursts of generalized, high-voltage, 1 to 2 Hz sharp wave activity. Neurologic symptoms disappeared following withdrawal of ceftriaxone. The possibility of ceftriaxone-induced neurotoxicity should be considered in patients developing neurological impairment during ceftriaxone use, and the discontinuation of the drug could lead to complete neurological improvement.
