Thrombotic Thrombocytopenic Purpura after Autologous Peripheral Blood Stem Cell Transplantation.
- Author:
Mi Hyang KIM
1
Author Information
1. Department of Laboratory Medicine, College of Medicine, Kosin University, Busan, Korea. mihakim@ns.kosinmed.or.kr
- Publication Type:Original Article
- Keywords:
Thrombotic thrombocytopenic purpura;
Autologous peripheral blood stem cell transplantation;
Plasma exchange
- MeSH:
Humans;
Lymphoma;
Peripheral Blood Stem Cell Transplantation*;
Plasma;
Plasma Exchange;
Purpura;
Purpura, Thrombotic Thrombocytopenic*;
Stem Cells
- From:The Korean Journal of Laboratory Medicine
2005;25(2):129-132
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Thrombotic thombocytopenic purpura (TTP) is a serious complication following stem cell trans-plantation (SCT). Although therapeutic plasma exchange offers an encouraging treatment modality in classic TTP, this does not appear to be effective in its management of TTP following SCT. This patient with malignant lymphoma developed TTP two months after autologous peripheral blood SCT and was effectively treated with plasma exchange and steroid therapy. Plasma exchange with fresh frozen plasma and albumin was performed 14 times in 40 days. Even though TTP may emerge as a complication of autologous peripheral blood SCT, this report suggests that the risk of developing TTP after autologous peripheral blood SCT may be low and a multiple course of plasma exchange may be an effective treatment in this patient.
