Association of the CD14/-159 C->T Polymorphism with Variations in Serum Lipoproteins in Healthy Population.
- Author:
Jung Sook HA
1
;
Nam Hee RYOO
;
Jae Ryong KIM
;
Dong Seok JUN
Author Information
1. Department of Laboratory Medicine, Keimyung University College of Medicine, Daegu, Korea. ksksmom@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
CD14;
Polymorphism;
Lipoprotein
- MeSH:
Adult;
Apolipoprotein A-I;
Cholesterol, LDL;
Gene Frequency;
Genotype;
Humans;
Immunoglobulin E;
Lipoproteins*;
Monocytes;
Myocardial Infarction;
Polymerase Chain Reaction;
Triglycerides
- From:The Korean Journal of Laboratory Medicine
2005;25(2):133-138
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The CD14 receptor is an important mediator for the activation of monocyte by lipo-polysaccharides. Recently described data indicate that the CD14/-159 C->T polymorphism is associated with elevated CD14 expression, decreased IgE and increased myocardial infarction risk. In the present study, we investigated the CD14/-159 C->T polymorphism to determine its association with lipid profile in healthy adults. METHODS: The CD14 promoter genotype was determined by polymerase chain reaction amplification-restriction fragment length polymorphism analysis in 156 healthy adults. Results of the CD14 promotor genotype were compared with total cholesterol, LDL, HDL, apo A1, apo B100, and triglyceride using one way ANOVA and independent T tests. RESULTS: The genotype frequencies were CC 13.5%, TT 35.9%, CT 50.6% and the T allele frequency was 61.2%; there was no association between CD14 promotor genotype and lipoprotein concentrations (P>0.05). CONCLUSIONS: Our results indicate that CD14/-159 C->T polymorphism is not associated with serum lipoprotein concentrations.
