Hypotensive Effect of Guanabenz Acetate(Rexitene(R))in Essential Hypertension;A Clinical Study.
10.4070/kcj.1989.19.1.117
- Author:
Jin Won JEONG
;
Yang Kyu PARK
;
Ock Kyu PARK
;
Jong Chun PARK
;
Myung Ho JEONG
;
Jeong Gwan CHO
;
Jeong Chaee KANG
- Publication Type:Original Article
- Keywords:
Guanabenz acetate;
Essential hypertension
- MeSH:
Blood Pressure;
Body Weight;
Cholesterol;
Creatinine;
Dizziness;
Guanabenz*;
Heart Rate;
Humans;
Hypertension;
Mouth;
Potassium;
Prospective Studies;
Sodium
- From:Korean Circulation Journal
1989;19(1):117-124
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To evaluate the hypertensive effect of guanbenz acetate, we performed a prospective clinical study for 10 weeks or more in 27 patients with essential hypertension(mean age: 51, mean supine blood pressure: 176/105mmHg). The daily dose of guanabenz acetate was 8-49 mg. The results were as follows; 1) After 2, 4, 6 and 8 weeks of treatment, average supine systolic and diastolic blood pressures reduced to 156/94, 150/94, 149/93 and 144/93mmHg respectively(all P<0.05). 2) Pulse rate decreased slightly from pre-treatment average of 75 beats per minute to 71 beats per minute at the end of the study(P<0.05). 3) Average body weight, serum levels of total cholesterol, AST, ALT, BUN, creatinine, sodium and potassium were not significantly changed from pre-treatment values. 4) A few side effects in order of frequency were dry mouth, dizziness, sedation, weakness, etc. We conclude that guanabenz acetate may be used as an effective first line antihypertensive agent in essential hypertension.
