Dermatophagoides Farinae-specific IgE and IgG4 Antibodies in Atopic Dermatitis Patients.
- Author:
Heun Jung CHO
;
Hyun Joo CHOI
;
Dong Kun KIM
;
Kwang Hoon LEE
- Publication Type:Original Article
- Keywords:
Atopic dermatitis;
D. farinae;
D. farinae-specific IgE;
IgG4
- MeSH:
Antibodies*;
Dermatitis, Atopic*;
Enzyme-Linked Immunosorbent Assay;
Humans;
Hypersensitivity;
Immunoglobulin E*;
Immunoglobulin G*;
Immunotherapy;
Pyroglyphidae*
- From:Korean Journal of Dermatology
1998;36(1):16-22
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The pathogenesis of atopic dermatitis is still unknown. Many reports have suggested that the house dust mite antigen may play a role in the pathogenesis of atopic dermatitis. The IgG4 allergen-specific subclass has been considered to be involved both in allergic reactions and associated with the appropriate response to allergen-specific immunotherapy. OBJECT: The purpose of this study was to evaluate the positive rate of the allergic prick test to D. farinae and the levels of D. farinae-specific IgE and Ig64. METHODS: We performed the allergy prick test, RAST for D. farinae-specific IgE and ELISA for D. farinae-specific IgG subclasses and compared the values between atopic dermatitis patients and normal controls. RESULTS: 1. D. farinae was the most common allergen in patients with atopic dermatitis and the positive rate of the allergic prick test was 61.0%. The positive rate of the allergic prick test and the positive rate to D. farinae increased as c]inical grading increased. 2. The Positive reaction rate of D. farinae-specific IgE(RAST) in those with atopic dermatitis was 68.8% and increased as the positive reactions of the allergic prick test to D. farinae and chnical grading increased. 3. Among the IgG subclasses, only the level of D. farinae-specific IgG4 was significantly higher in atopic dermatitis than normal controls. 4. The level of D. farinae-specific IgG4 showed a tendency to decrease in accordance with the clinical severity grades. CONCLUSION: These results suggested that D. farinae might play an important role in the development of atopic dermatitis and well-designed studies should continue to be performed in order to delineate the biological significance of IgG4.
