Application of Iron Related Magnetic Resonance Imaging in the Neurological Disorders.
10.14253/kjcn.2014.16.1.1
- Author:
Tae Hyoung KIM
1
;
Jae Hyeok LEE
Author Information
1. Department of Neurology, Pusan National University Yangsan HospitalResearch Institute for Convergence of Biomedical Science and Technology, Yangsan, Korea. jhlee.neuro@pusan.ac.kr
- Publication Type:Review
- Keywords:
Iron;
Neurodegenerative disorders;
MRI
- MeSH:
Aging;
Alzheimer Disease;
Brain;
Diagnosis;
DNA;
Friedreich Ataxia;
Iron*;
Magnetic Resonance Imaging*;
Multiple Sclerosis;
Myelin Sheath;
Nervous System Diseases*;
Neurodegenerative Diseases;
Oxygen;
Parkinson Disease;
Reactive Oxygen Species;
Synaptic Transmission
- From:Korean Journal of Clinical Neurophysiology
2014;16(1):1-7
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Iron is an important element for brain oxygen transport, myelination, DNA synthesis and neurotransmission. However, excessive iron can generate reactive oxygen species and contribute neurotoxicity. Although brain iron deposition is the natural process with normal aging, excessive iron accumulation is also observed in various neurological disorders such as neurodegeneration with brain iron accumulation, Parkinson's disease, Alzheimer's disease, multiple sclerosis, Friedreich ataxia, and others. Magnetic resonance image (MRI) is a useful method for detecting iron deposits in the brain. It can be a powerful tool for diagnosis and monitoring, while furthering our understanding of the role of iron in the pathophysiology of a disease. In this review, we will introduce the mechanism of iron toxicity and the basics of several iron-related MRI techniques. Also, we will summarize the previous results concerning the clinical application of such MR imagings in various neurological disorders.
