Results of Radioiodine Treatment for Distant Metastases of Differentiated Thyroid Carcinoma.
- Author:
Yu Kyeong KIM
;
June Key CHUNG
;
Seok Ki KIM
;
Jung Seok YEO
;
Do Joon PARK
;
Jae Min JEONG
;
Dong Soo LEE
;
Bo Youn CHO
;
Myung Chul LEE
- Publication Type:Original Article
- Keywords:
differentiated thyroid cancer;
lung metastasis;
bone metastasis;
I-131 treatment
- MeSH:
Atrial Natriuretic Factor;
Humans;
Iodine;
Lung;
Neoplasm Metastasis*;
Thyroid Gland*;
Thyroid Neoplasms*
- From:Korean Journal of Nuclear Medicine
2000;34(2):107-118
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the effectiveness of radioiodine treatment for metastatic thyroid carcinoma, we reviewed results of radioactive iodine treatment in patients with functional lung or bone metastases. MATERIALS ANF METHODS: Of 760 patients who were treated for differentiated thyroid cancer between 1984 and 1998, we detected pulmonary metastases and bone metastases in 76 patients (10.0%) and 20 patients (2.6%), respectively. Among them, we could evaluate the effectiveness of I-131 therapy in 53 patients with lung metastases and 15 patients with bone metastases. RESULTS:Of 53 patients who received I-131 therapy with a mean cumulative dose of 26.2 GBq (1.1-84.4 GBq) for pulmonary metastases, metastatic lung lesions completely resolved in 19 patients (35.8%) and improved in 22 patients (41.5%). In 13 of 19 patients with complete remission of pulmonary metastases, the total accumulated dose of I-131 was less than 18.5 GBq. We found 43 sites of metastatic bone lesions in 15 patients with bone metastases. Of 29 lesions which received I-131 therapy, metastatic lesions improved in 14 sites (48.3%), but did not change or progress in 15 sites (51.7%) despite the I-131 therapy. Three lesions were completely cured with a combination treatment of surgery(+/- external radiotherapy) and I-131 therapy, and the other 11 lesions improved. CONCLUSION: Radioactive iodine treatment gives favorable results for pulmonary metastases. However, for bone metastases, there might be a need to use combination therapy including I-131 and surgery or external irradiation.
