Histopathological features of gastric mucosa before and after eradication of H.pylori in patients with operated perforated gastroduodenal ulceration
- Author:
Trung Thien Tran
- Publication Type:Journal Article
- Keywords:
Gastroduodenal ulcer
- MeSH:
Peptic Ulcer;
Helicobacter pylori;
surgery
- From:Journal of Preventive Medicine
2001;11(4):36-40
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
98 patients with perforated peptic ulcer were treated by simple surgical closure followed by H.pylori eradication. Effect of H.pylori eradication was demonstrated by improvement or resolution of histopathological lesions of chronic gastritis 97.95% compared with 60.2% in pre and postreatment lesions (p<0.0001), atrophy 20.83% vs 4.16% (p<0.0001) and intestinal metaplasia 18.75% vs 9.37% (p < 0.005). After successful eradication of H.pylori, these lesions were restored and improved significantly in patients received a new triple therapy for 7 days (OCA-7).
