Adverse effect of excess body weight on survival in cervical cancer patients after surgery and radiotherapy.
- Author:
Yunseon CHOI
1
;
Ki Jung AHN
;
Sung Kwang PARK
;
Heunglae CHO
;
Ji Young LEE
Author Information
- Publication Type:Original Article
- Keywords: Overweight; Obesity; Survival; Cervical cancer; Radiotherapy
- MeSH: Body Mass Index; Body Weight*; Diagnosis; Disease-Free Survival; Drug Therapy; Follow-Up Studies; Humans; Lymph Nodes; Medical Records; Neoplasm Metastasis; Obesity; Overweight; Radiotherapy*; Recurrence; Retrospective Studies; Thinness; Uterine Cervical Neoplasms*
- From:Radiation Oncology Journal 2017;35(1):48-54
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: This study aimed to assess the effects of body mass index (BMI) on survival in cervical cancer patients who had undergone surgery and radiotherapy (RT). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 70 cervical cancer patients who underwent surgery and RT from 2007 to 2012. Among them, 40 patients (57.1%) had pelvic lymph node metastases at the time of diagnosis. Sixty-seven patients (95.7%) had received chemotherapy. All patients had undergone surgery and postoperative RT. Median BMI of patients was 22.8 kg/m² (range, 17.7 to 35.9 kg/m²). RESULTS: The median duration of follow-up was 52.3 months (range, 16 to 107 months). Twenty-four patients (34.3%) showed recurrence. Local failure, regional lymph nodal failure, and distant failure occurred in 4 (5.7%), 6 (8.6%), and 17 (24.3%) patients, respectively. The 5-year actuarial pelvic control rate was 83.4%. The 5-year cancer-specific survival (CSS) and disease-free survival (DFS) rates were 85.1% and 65.0%, respectively. The presence of pelvic lymph node metastases (n = 30) and being overweight or obese (n = 34, BMI ≥ 23 kg/m²) were poor prognostic factors for CSS (p = 0.003 and p = 0.045, respectively). Of these, pelvic lymph node metastasis was an independent prognostic factor (p = 0.030) for CSS. CONCLUSION: Overweight or obese cervical cancer patients showed poorer survival outcomes than normal weight or underweight patients. Weight control seems to be important in cervical cancer patients to improve clinical outcomes.
