Multimodal Treatments of Cystine Stones: An Observational, Retrospective Single-Center Analysis of 14 Cases.
10.4111/kju.2014.55.8.515
- Author:
Myungsun SHIM
1
;
Hyung Keun PARK
Author Information
1. Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. hkpark@amc.seoul.kr
- Publication Type:Original Article ; Evaluation Studies ; Observational Study
- Keywords:
Calculi;
Cystinuria;
Nephrolithiasis;
Urolithiasis
- MeSH:
Adolescent;
Adult;
Child;
Combined Modality Therapy;
Cystine/*analysis;
Cystinuria/complications;
Female;
Humans;
Hydrogen-Ion Concentration;
Kidney Calculi/chemistry/pathology/therapy;
Lithotripsy/methods;
Male;
Nephrostomy, Percutaneous/methods;
Recurrence;
Reoperation;
Retrospective Studies;
Treatment Outcome;
Ureteral Calculi/chemistry/pathology/therapy;
Urinary Calculi/chemistry/etiology/pathology/*therapy;
Young Adult
- From:Korean Journal of Urology
2014;55(8):515-519
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To document the experiences of a single institution in evaluating the clinical courses and treatment outcomes of patients with cystine stones. MATERIALS AND METHODS: The clinical data of 14 patients with cystine stones who were treated at our institution from March 1994 to July 2012 were reviewed. These data included age at first visit, gender, family history, body mass index, presence of a single kidney, stone locations, stone burden, routine urinalysis, and culture. In addition, we also analyzed data on surgery, shock wave lithotripsy, medical treatment, stone recurrence or regrowth, and overall treatment success rates. RESULTS: The mean age of our patients at their first visit was 19.6+/-5.0 years, and eight patients were males. The median stone burden and mean urine pH before each surgery were 6.5 cm2 and 6.5+/-0.9, respectively. Two patients had a family history of cystine stones. Patients underwent surgery an average of 2.7 times. The median interval between surgeries was 27.3 months, and 1 open surgery, 12 percutaneous nephrolithotomies, and 25 ureterorenoscopies were performed. Potassium citrate or sodium bicarbonate was used in nine cases. D-Penicillamine was continuously used in three patients. Patients had an average incidence of 3.2 recurrences or regrowth of stones during the median follow-up period of 60.5 months. CONCLUSIONS: Patients with cystine stones have high recurrence or regrowth rates and relatively large stone burdens. Adequate treatment schedules must therefore be established in these cases to prevent possible deterioration of renal function.
