Analysis of the Effect of Renal Replacement Therapy: In the Prolonged Extracorporeal Membrane Oxygenation Patients.
- Author:
Hyun Seok PARK
1
;
Seong Joon CHO
;
Se Min RYU
;
Sung Min PARK
;
Ki Hwan KIM
;
Sun Hye LIM
;
Hee Kon SHIN
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Kangwon National University School of Medicine, Korea. bluecorr@naver.com
- Publication Type:Original Article
- Keywords:
Extracorporeal membrane oxygenation;
Pulsatile flow;
Renal replacement therapy;
Renal insufficiency;
Ultrafiltration
- MeSH:
Creatinine;
Extracorporeal Membrane Oxygenation*;
Humans;
Pulsatile Flow;
Renal Insufficiency;
Renal Replacement Therapy*;
Ultrafiltration
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2014;47(4):373-377
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: This paper aimed to verify the effects of renal replacement therapy on changing the levels of serum creatinine for different veno-arterial and veno-venous configurations in prolonged extracorporeal membrane oxygenation (ECMO) patients. METHODS: The subjects were chosen 71 patients who had undergone more than 1,440 minutes (24 hours) of the therapy from among 117 patients who had undergone ECMO insertion between January 2008 and December 2012. The patients were separated into the veno-arterial configuration group I (51 patients) and the veno-venous configuration group II (20 patients). The difference in the level of serum creatinine (DeltaCr) between before or just after ECMO insertion (CrI) and the level when the pump time was between 2,880 and 4,320 minutes (CrF) was checked (DeltaCr=CrF-CrI), and the average DeltaCr for each group was compared using a Student t-test at the confidence interval (CI) of 95%. RESULTS: The change in the level of serum creatinine was an increase of 0.341 mg/dL (sigma=0.9202) for group I and a decrease of 0.120 mg/dL (sigma=1.5292) for group II. The change was significantly high for group I (p=0.011, CI=95%). Meanwhile, within group I, when renal replacement therapy was not done, there was a significant increase in the level of serum creatinine (p=0.009, CI=95%). CONCLUSION: For ECMO insertion patients whose pump time was more than 1,440 minutes, there was a significant change in the level of serum creatinine when renal replacement therapy was not done, for the veno-arterial configuration of group I.
