Expression of the Brother of the Regulator of Imprinted Sites Gene in the Sputum of Patients with Lung Cancer.
- Author:
Hae Young LEE
1
;
Jong In KIM
;
Sung Ho CHO
;
Taek Yong KO
;
Hyun Su KIM
;
Sung Dal PARK
;
Sung Rae CHO
;
Hee Kyung CHANG
;
Guk Jin HWANG
;
Sang Bong JUNG
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Kosin University Gospel Hospital, Kosin University College of Medicine, Korea. charlie822@empas.com
- Publication Type:Original Article
- Keywords:
Lung neoplasms;
Brother of the regulator of imprinted sites;
Reverse transcription;
Polymerase chain reaction
- MeSH:
Adenocarcinoma;
Carcinoma, Squamous Cell;
Humans;
Immunotherapy;
Lung Neoplasms*;
Lymph Nodes;
Melanoma;
Neoplasm Metastasis;
Oncogenes;
Polymerase Chain Reaction;
Reverse Transcription;
RNA;
RNA, Messenger;
Siblings*;
Sputum*
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2014;47(4):378-383
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Brother of the regulator of imprinted sites (BORIS) is a putative new oncogene that is classified as a cancer germline gene; however, its role in the development of cancer is unclear. This study investigated the expression of BORIS in lung cancer and its clinical implications. METHODS: The expression of BORIS messenger ribonucleic acid (mRNA) in the sputum of 100 patients with lung cancer (50 with squamous cell carcinoma, 36 with adenocarcinoma, and 14 with small-cell carcinoma) was evaluated by reverse transcription polymerase chain reaction. RESULTS: The overall expression rate of BORIS in patients with lung cancer was 36.0%: 19 of 50 squamous cell carcinomas (38.0%), 13 of 36 adenocarcinomas (36.1%), and 4 of 14 (28.6%) small-cell carcinomas. There was no significant difference in the BORIS expression according to age, gender, or histologic type. However, the mRNA expression of BORIS was significantly related to the pathologic cancer stage (p=0.004) and lymph node metastasis (p=0.001). The expression of the melanoma antigen gene family A1-6 was not associated with the expression of BORIS. CONCLUSION: Our results suggest that the expression of BORIS might be a negative prognostic factor in lung cancers and implicate BORIS as a molecular target for immunotherapy.
