The Influence of Apolipoprotein E epsilon4 and Lipid Profile on Cognitive Function in Community-Dwelling Elders with Mild Cognitive Impairment.
- Author:
Tae Ho KIM
1
;
Seok Woo MOON
Author Information
1. Department of Neuropsychiatry, Konkuk University School of Medicine, Seoul, Korea. hessem@kku.ac.kr
- Publication Type:Original Article
- Keywords:
Mild cognitive impairment;
Apolipoprotein E;
high-density lipoprotein cholesterol;
Korean version of Consortium to Establish a Registry of Alzheimer's Disease;
Cognitive function
- MeSH:
Aged;
Alzheimer Disease;
Apolipoproteins;
Apolipoproteins E;
Cholesterol;
Humans;
Lipoproteins;
Male;
Memory, Episodic;
Mild Cognitive Impairment;
Neuropsychological Tests
- From:Korean Journal of Psychopharmacology
2011;22(1):49-56
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The aim of this study is to examine the relationship between lipid profiles including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-cholesterol), and low-density lipoprotein cholesterol (LDL-cholesterol) and cognitive function by the occurrence of the apolipoprotein E (APOE) epsilon4 in the community-dwelling elderly individuals with mild cognitive impairment (MCI). METHODS: The total number of subjects was 203 (77 men and 126 women) who were diagnosed with MCI from a Korean project of "Early Detection of Dementia". Aged 65-85 years were included in this analysis. The eight neuropsychological domain from the Korean version of Consortium to Establish a Registry of Alzheimer's Disease neuropsychological test battery (CERAD-K, NP) were conducted to test subjects. The lipid profiles of all subjects were measured including TC, TG, HDL-cholesterol, and LDL-cholesterol levels and the correlation between the lipid levels and the neuropsychological test scores was analyzed by the occurrence of the APOE epsilon4. RESULTS: There was significant correlation between HDL-C and Word List Recall Test (WLRT) of the neuropsychological test score in CERAD-K (NP) in the presence of APOE epsilon4 (WLRT/HDL-C: r=0.163, p<0.05). CONCLUSION: The HDL-C level might be correlated with verbal episodic memory domain in CERAD-K (NP) test in the presence of APOE epsilon4 in community-dwelling elders diagnosed with MCI.
