Kidney Transplantation from a Donor Following Cardiac Death Supported with Extracorporeal Membrane Oxygenation.
10.3346/jkms.2012.27.2.115
- Author:
Jong Hoon LEE
1
;
Sung Yeon HONG
;
Chang Kwon OH
;
You Sun HONG
;
Hyunee YIM
Author Information
1. Department of Surgery, Ajou University, School of Medicine, Suwon, Korea. ohck@ajou.ac.kr
- Publication Type:Case Reports
- Keywords:
Extracorporeal Membrane Oxygenation;
Kidney Transplantation;
Organ Donation After Cardiac Death
- MeSH:
Adult;
*Death;
*Extracorporeal Membrane Oxygenation;
Female;
Glomerular Filtration Rate;
Glucose/chemistry;
Humans;
*Kidney Transplantation;
Male;
Mannitol/chemistry;
Middle Aged;
*Organ Preservation;
Potassium Chloride/chemistry;
Procaine/chemistry;
Retrospective Studies;
Time Factors;
Tissue Donors
- From:Journal of Korean Medical Science
2012;27(2):115-119
- CountryRepublic of Korea
- Language:English
-
Abstract:
To expand the donor pool, organ donation after cardiac death (DCD) has emerged. However, kidneys from DCD donors have a period of long warm ischemia between cardiac arrest and the harvesting of the organs. Recently, we used extracorporeal membrane oxygenation (ECMO) to minimize ischemic injury during 'no touch' periods in a Maastricht category II DCD donor and performed two successful kidney transplantations. The kidneys were procured from a 49-yr-old male donor. The warm ischemia time was 31 min, and the time of maintained circulation using ECMO was 7 hr 55 min. The cold ischemia time was 9 hr 15 min. The kidneys were transplanted into two recipients and functioned immediately after reperfusion. The grafts showed excellent function at one and three months post-transplantation; serum creatinine (SCr) levels were 1.0 mg/dL and 0.8 mg/dL and the estimated glomerular filtration rates (eGFR) were 63 mL/min/1.73 m2 and 78 mL/min/1.73 m2 in the first recipient, and SCr levels were 1.1 mg/dL and 1.0 mg/dL and eGFR were 56 mL/min/1.73 m2 and 64 mL/min/1.73 m2 in the second recipient. In conclusion, it is suggested that kidney transplantation from a category II DCD donor assisted by ECMO is a reasonable modality for expanding donor pool.
