Pathophysiological Role of Hormones and Cytokines in Cancer Cachexia.
10.3346/jkms.2012.27.2.128
- Author:
Hyun Jung KIM
1
;
Han Jo KIM
;
Jina YUN
;
Kyoung Ha KIM
;
Se Hyung KIM
;
Sang Cheol LEE
;
Sang Byung BAE
;
Chan Kyu KIM
;
Nam Su LEE
;
Kyu Taek LEE
;
Seong Kyu PARK
;
Jong Ho WON
;
Hee Sook PARK
;
Dae Sik HONG
Author Information
1. Division of Hematology & Oncology, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Korea. dshong@schmc.ac.kr
- Publication Type:Original Article
- Keywords:
Adiponectin;
Cachexia;
Cytokines;
Ghrelin;
Leptin
- MeSH:
Adiponectin/analysis;
Aged;
Antineoplastic Agents/therapeutic use;
Cachexia/*physiopathology;
Colorectal Neoplasms/drug therapy/*metabolism/mortality;
Cytokines/*analysis;
Female;
Follow-Up Studies;
Ghrelin/analysis;
Humans;
Interferon-gamma/analysis/physiology;
Interleukin-6/analysis;
Leptin/analysis;
Lung Neoplasms/drug therapy/*metabolism/mortality;
Male;
Middle Aged;
Peptide Hormones/*analysis;
Prognosis;
Prospective Studies;
Survival Rate;
Tumor Necrosis Factor-alpha/analysis;
Weight Gain;
Weight Loss
- From:Journal of Korean Medical Science
2012;27(2):128-134
- CountryRepublic of Korea
- Language:English
-
Abstract:
We investigated the role of fasting hormones and pro-inflammatory cytokines in cancer patients. Hormones (ghrelin, adiponectin, and leptin) and cytokines (TNF-alpha, IFN-gamma, and IL-6) were measured by ELISA or RIA in lung cancer and colorectal cancer patients before the administration of cancer therapy, and measurements were repeated every 2 months for 6 months. From June 2006 to August 2008, 42 patients (19 with colorectal cancer and 23 with lung cancer) were enrolled. In total, 21 patients were included in the cachexia group and the others served as a comparison group. No significant difference in the initial adiponectin, ghrelin, TNF-alpha, IFN-gamma, or IL-6 level was observed between groups, although leptin was significantly lower in cachectic patients than in the comparison group (15.3 +/- 19.5 vs 80.9 +/- 99.0 pg/mL, P = 0.007). During the follow-up, the patients who showed a > 5% weight gain had higher ghrelin levels after 6 months. Patients exhibiting elevated IL-6 levels typically showed a weight loss > 5% after 6 months. A blunted adiponectin or ghrelin response to weight loss may contribute to cancer cachexia and IL-6 may be responsible for inducing and maintaining cancer cachexia.
