The Ability of beta-Cells to Compensate for Insulin Resistance is Restored with a Reduction in Excess Growth Hormone in Korean Acromegalic Patients.
10.3346/jkms.2012.27.2.177
- Author:
Soo Kyoung KIM
1
;
Sunghwan SUH
;
Ji In LEE
;
Kyu Yeon HUR
;
Jae Hoon CHUNG
;
Moon Kyu LEE
;
Yong Ki MIN
;
Jae Hyeon KIM
;
Jong Hyun KIM
;
Kwang Won KIM
Author Information
1. Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. kw1234@skku.edu
- Publication Type:Original Article
- Keywords:
Insulin Resistance;
Acromegaly
- MeSH:
Acromegaly/*diagnosis/etiology/metabolism;
Adult;
Asian Continental Ancestry Group;
Blood Glucose/analysis;
C-Peptide/analysis;
Diabetes Mellitus/epidemiology;
Female;
Glucose Tolerance Test;
Human Growth Hormone/secretion;
Humans;
Insulin/blood/secretion;
*Insulin Resistance;
Insulin-Secreting Cells/cytology/*physiology;
Male;
Middle Aged;
Prediabetic State/epidemiology;
Republic of Korea
- From:Journal of Korean Medical Science
2012;27(2):177-183
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to assess the prevalence of diabetes and to study the effects of excess growth hormone (GH) on insulin sensitivity and beta-cell function in Korean acromegalic patients. One hundred and eighty-four acromegalic patients were analyzed to assess the prevalence of diabetes, and 52 naive acromegalic patients were enrolled in order to analyze insulin sensitivity and insulin secretion. Patients underwent a 75 g oral glucose tolerance test with measurements of GH, glucose, insulin, and C-peptide levels. The insulin sensitivity index and beta-cell function index were calculated and compared according to glucose status. Changes in the insulin sensitivity index and beta-cell function index were evaluated one to two months after surgery. Of the 184 patients, 17.4% were in the normal glucose tolerance (NGT) group, 45.1% were in the pre-diabetic group and 37.5% were in the diabetic group. The insulin sensitivity index (ISI0,120) was significantly higher and the HOMA-IR was lower in the NGT compared to the diabetic group (P = 0.001 and P = 0.037, respectively). The ISI0,120 and disposition index were significantly improved after tumor resection. Our findings suggest that both insulin sensitivity and beta-cell function are improved by tumor resection in acromegalic patients.
