Increased Estimated 10-Year Risk for Cardiovascular Disease Assessed Using the Pooled Cohort Equation in Non-Diabetic Subjects According to Increasing HbA1c Levels.
10.12997/jla.2015.4.2.123
- Author:
Hyung Geun OH
1
;
Eun Jung RHEE
Author Information
1. Department of Neurology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.
- Publication Type:Original Article
- Keywords:
Pooled Cohort Equation;
10-year cardiovascular disease risk;
Prediabetes
- MeSH:
Blood Glucose;
Body Mass Index;
Cardiovascular Diseases*;
Cholesterol;
Cohort Studies*;
Fasting;
Hemoglobin A, Glycosylated;
Insulin;
Mass Screening;
Odds Ratio;
Prediabetic State
- From:Journal of Lipid and Atherosclerosis
2015;4(2):123-130
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: In 2013, a new risk calculator known as the Pooled Cohort Equation (PCE) was introduced with the new cholesterol guideline. We aimed to calculate the 10-year atherosclerotic cardiovascular disease (ASCVD) risk using PCE in non-diabetic Korean subjects with glycated hemoglobin (HbA1c) lower than 6.5%. METHODS: A total of 17,519 participants were evaluated in a health screening program. The 10-year ASCVD risk was calculated using the PCE. Subjects with underlying diabetes or HbA1c > or =6.5% were excluded. Subjects were divided into four groups according to fasting blood glucose (FBG) and HbA1c levels: FBG <100 mg/dL, 100< or =FBG<110 mg/dL, 110< or =FBG<120 mg/dL, and FBG > or =120 mg/dL; HbA1c <5.5%, 5.5%< or =HbA1c<5.6%, 5.6%< or =HbA1c<5.8%, and HbA1c > or =5.8%. RESULTS: The mean 10-year ASCVD risk significantly increased as FBG increased from <100 mg/dL to >120 mg/dL in the four divided groups (2.6%, 3.3%, 3.8%, 4.1%; p<0.01), and as HbA1c increased from <5.5% to >5.8% (2.4%, 2.7%, 3.0%, 3.6%; p<0.01). The odds ratio for 10-year ASCVD risk > or =10% significantly increased from group I to IV according to FBG and HbA1c levels after adjusting for age, body mass index and fasting insulin level (1.187, 1.753, and 2.390 vs. 1.0 in the lowest FBG group; 1.626, 1.574, and 1.645 vs. 1.0 in the lowest HbA1c group). CONCLUSION: The 10-year ASCVD risk calculated using the PCE significantly increased as the FBG and HbA1c increased even in Korean subjects without underlying diabetes.
