Prick Test Reactions in the Patients of Allergic Rhinitis, Asthma and Urticatia.
- Author:
Si Yong KIM
;
Chung Won KIM
;
Won HOUH
;
Suh Byung DO
- Publication Type:In Vitro ; Original Article
- MeSH:
Allergens;
Asthma*;
Diagnosis;
Histamine Release;
Humans;
Immunoglobulin E;
Mast Cells;
Rhinitis*;
Sensitivity and Specificity;
Skin Tests;
Urticaria
- From:Korean Journal of Dermatology
1981;19(1):77-85
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Since the recognition that certain conditions such as allergic rhinitis, asthma and urticaria are due to the substances which are innocuous to the individuals, it has been a common practice to establish a diagnosis by reexposure of the individual to the suspected subsutance. Their pathogenesis was classified into immunologic and nonimmunologic mechanism. The immunologic mechanism in such conditions is mainly due to interaction between antigen and IgE skin-sensitizing antibody bound to tissue mast cells. There are two approaching methods in evaluating allergic disease. One is in vitro test which includes R.A.S.T. and leukocukocyte histamine release test and the other method is in vivo test which includes provocation test and skin tests. Prick test, a kind of skin test, is most frequently used in clinical procedure because of its simplicity and safety of appliation and better correlation with clinical history as well as specificity and highly reproducibility. It is well accepted that the therapeutic principle in allergic disease is to find out the causative allergens and get rid of them from patient's environment. If the causative allergens are inavoidable, the patient should be treated by means of specific hyposensitization. In evaluating allergic disease, the patient's clinical history is most important. (countinued..)
