Electronmicroscopic Study of Collodion Baby.
- Author:
Jung Bock LEE
;
Seung Hun LEE
;
Sung Nack LEE
;
Chung Sook KIM
- Publication Type:Original Article
- MeSH:
Collodion*;
Desmosomes;
Extracellular Space;
Extremities;
Genotype;
Humans;
Ichthyosiform Erythroderma, Congenital;
Ichthyosis;
Ichthyosis, Lamellar;
Infant;
Intermediate Filaments;
Keratinocytes;
Membranes;
Parturition;
Skin;
Skin Diseases
- From:Korean Journal of Dermatology
1981;19(1):93-98
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Collodion baby is one of the rare congenital ichthyosiform dermatoses first described by Seeligmann in 1841. It is a phenotypic expression of several genotypes such as aex-linked ichthyosis and bullous and non-bullous congenital ichthyosiform erythroderma. The infant is enveloped in a smooth and shiny collodion-like membrane at birth, which temporarily may deform the facial feature and extremities. The skin clears almost completely in the first month of life and remains free of ichthyosis. Etiology of this condition is still controversy, but it has been known that abnormalities of other organs are not accompanied but prematurity frequently. We present two cases of collodion baby with electron microscopic findings. In the upper stratum spinosum, keratinosomes and desomoaomes were increased in the keratinocytes, and intercellular spaces widened, however, desmosomes and tonofilaments were intact. These findings were similar to those of nonbullous congenital ichthyosiform erythroderma. But in some widened intercellular spaces of the upper stratum spinosum, multiple finely granular electron dense particles were seen within large round membranous structures.
