Pemphigus Vulgaris Developed During Pregnancy.
- Author:
Chang Woo LEE
;
Seon Hoon KIM
;
Hee Joon YU
- Publication Type:In Vitro ; Original Article
- MeSH:
Autoantibodies;
Azathioprine;
Basement Membrane;
Diagnosis;
Epidermis;
Fluorescent Antibody Technique;
Fluorescent Antibody Technique, Direct;
Humans;
Immunoglobulins;
Microscopy;
Pemphigus*;
Pregnancy*;
Skin
- From:Korean Journal of Dermatology
1981;19(1):99-103
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We present a case of pemphigus vulgaris developed during pregnancy. The clinical features of this patient were similar to those of hetpes gestationis. By immunofluorescence studies we found that the patient's serum contained autoantibodies to intercellular substance of epidermis. Direct immunofluorescence microscopy of a perilesional skin also demontrated immunoglobulin deposition in the intercellular areas. Additionally we did in vitro C3 staining for further confirmation of the diagnosis but it was negative in basement membrane zone. This patient was initially treated with corticosteroid and azathioprine. Several months later gold compound was given instead of azathioprine and corticosteroid with good therapeutic response.
