The Effects of Lipoprotein(a) on Coronary Stent Restenosis.
10.4070/kcj.2001.31.5.476
- Author:
Jay Young RHEW
;
Myung Ho JEONG
;
Young Joon HONG
;
Weon KIM
;
Kyung Tae KANG
;
Sang Hyun LEE
;
Jong Cheol PARK
;
Nam Ho KIM
;
Kun Hyung KIM
;
Sung Hwa KIM
;
Young Keun AHN
;
Jeong Gwan CHO
;
Byoung Hee AHN
;
Soon Pal SUH
;
Jong Chun PARK
;
Sang Hyung KIM
;
Jung Chaee KANG
- Publication Type:Original Article
- MeSH:
Apoprotein(a);
Atherosclerosis;
Binding Sites;
Coronary Vessels;
Diagnosis;
Female;
Follow-Up Studies;
Heart;
Humans;
Jeollanam-do;
Lipoprotein(a)*;
Myocardial Infarction;
Plasma;
Plasminogen;
Plasminogen Activators;
Risk Factors;
Stents*;
Ventricular Function, Left
- From:Korean Circulation Journal
2001;31(5):476-483
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Lipoprotein (a) [Lp(a)] contains apolipoprotein(a), which is a structural homologue of plasminogen and competes with it for binding sites. It also acts by increasing plasminogen activator inhibitor-1 expression. The objective of this study was to evaluate the relationship between Lp(a) levels and restenosis rate after successful coronary stent placement. METHODS: The study included 306 patients who underwent coronary stent placement and follow-up coronary angiogram at Chonnam National University Hospital from August 1996 to June 2000. Restenosis rate was analyzed according to the level of Lp(a); Group I with high Lp(a) (n=7, Lp(a) 36 mg/dL, 58.98.8 years, female: 35.1%) and Group II with low Lp(a) (n=29, Lp(a) < 36 mg/dL, 57.79.8 years, female: 18.8%). RESULTS: 1) There was no significant differences in risk factors of atherosclerosis, clinical diagnosis, the number of involved coronary artery, left ventricular function, angiographic lesion characteristics by American College of Cardiology/American Heart Association clasification and Thrombolysis In Myocardial Infarction flow in two groups. 2) Angiographic restenosis rates were not different between two groups (group I : 33.8%, group II : 35.4%). CONCLUSION: Plasma Lp(a) levels are not related with the angiographic restenosis rate after coronary stent placement.
