Rocuronium Pretreatment for Prevention of Myalgia Following Succinylcholine Administration.
10.4097/kjae.1999.36.5.777
- Author:
Jae Hwan KIM
1
;
Seon Young JEON
;
Hun CHO
;
Hye Won LEE
;
Hye Ja LIM
;
Seong Ho CHANG
;
Seok Min YOON
Author Information
1. Department of Anesthesiology, College of Medicine, Korea University, Seoul, Korea.
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Blood, potassium, creatine kinase;
Muscle, skeletal, fasciculations, myalgia;
Neuromuscular relaxants, succinylcholine, rocuronium, vecuronium
- MeSH:
Creatine Kinase;
Fasciculation;
Humans;
Incidence;
Myalgia*;
Potassium;
Prospective Studies;
Succinylcholine*;
Vecuronium Bromide
- From:Korean Journal of Anesthesiology
1999;36(5):777-782
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The purpose of this study was to assess the effect of rocuronium pretreatment on the succinylcholine induced biochemical changes and fasciculations, myalgia and to compare it with vecuronium pretreatment. METHODS: We have studied 60 patients undergoing minor elective surgery, in a prospective double blinded method. Three groups of 20 patients each were pretreated with saline 0.01 ml/kg (group C), rocuronium 0.05 mg/kg (group R), or vecuronium 0.007 mg/kg (group V). Three minutes after the pretreatment, 1.5 mg/kg succinylcholine was injected. Serum potassium five minutes after succinylcholine and creatine kinase 24 hr after operation were measured. Fasciculations and postoperative myalgia at 24 and 48 h were evaluated. RESULTS: The increase in creatine kinase and incidence of fasciculations were lowest in the rocuronium group (33 IU/L; 15%) and followed by vecuronium group (58 IU/L; 50%) and highest in the control group (101 IU/L; 100%). The increase in serum potassium concentration (0.3 mEq/L) was not attenuated by any regimen. The incidence of postoperative myalgia on day 1 and day 2 was lower in the rocuronium (40%, 30%) and the vecuronium (50%; 35%) group than control group (85%; 75%). CONCLUSIONS: Rocuronium pretreatment is more effective in reducing creatine kinase rise and fasciculations after succinylcholine than vecuronium. However rocuronium and vecuronium are also effective in preventing postoperative myalgia.
