A Comparison of the Effect of Nalbuphine-Ketorolac and Morphine-Fentanyl-Ketorolac for Postoperative Analgesia with the Use of IV-PCA.
10.4097/kjae.1999.36.5.841
- Author:
Seong Tak PARK
1
;
Sang Tae KIM
Author Information
1. Department of Anesthesiology, Choi Hospital.
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Analgesia, patient-controlled, intravenous;
Analgesics, fentanyl, morphine, nalbuphine;
Pain, postoperative
- MeSH:
Analgesia*;
Analgesia, Patient-Controlled;
Analgesics, Opioid;
Fentanyl;
Humans;
Hysterectomy;
Morphine;
Nalbuphine;
Nausea;
Pain, Postoperative;
Passive Cutaneous Anaphylaxis;
Peritoneum;
Pruritus;
Respiratory Insufficiency;
Urinary Retention;
Vomiting
- From:Korean Journal of Anesthesiology
1999;36(5):841-845
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Intravenous patient-controlled analgesia (IV-PCA) is a safe and effective method for post-operative pain control. But opioids used in IV-PCA result in some side effects such as respiratory depression, nausea, vomiting, itching and urinary retention. Nalbuphine, an agonist-antagonist, has a considerable analgesic effect without serious complications. This study was designed to evaluate the effectiveness of post-operative pain relief in PCA-administered nalbuphine-ketorolac and morphine-fentanyl-ketorolac. METHODS: Patients scheduled for total abdominal hysterectomy were randomly assigned in a double-blind manner into one of two groups. Group 1 (n=24) and Group 2 (n=28) received nalbuphine-ketorolac or morphine-fentanyl-ketorolac, respectively. All patients received same background infusion rate (2 ml/hr), PCA dose (0.5 ml) and lockout interval (15 min) just after peritoneum closure. And post-operative pain scores were recorded with numerical rating scale (NRS) at 1, 2, 6, 12, 24 and 48 hr after operation. RESULTS: The pain control effect in group 1 was more effective than in group 2. The patients' satisfaction was more superior in group 1. And the number of using PCA button was more frequent in group 2. CONCLUSION: This study suggests that intravenous nalbuphine is an excellent alternative to morphine and fentanyl for postopertive pain control.
