Hydrogen Peroxide Upregulates TNF-Related Apoptosis-Inducing Ligand (TRAIL) Expression in Human Astroglial Cells, and Augments Apoptosis of T Cells.
10.3349/ymj.2006.47.4.551
- Author:
Daeho KWON
1
;
In Hong CHOI
Author Information
1. Department of Microbiology, Ajou University School of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Astroglial cells;
hydrogen peroxide;
TRAIL;
cyclosporin A;
apoptosis;
oxidative stress;
neuroimmunology
- MeSH:
*Up-Regulation;
TNF-Related Apoptosis-Inducing Ligand/*biosynthesis;
T-Lymphocytes/*metabolism;
Ribonucleases/metabolism;
Oxidative Stress;
Immunosuppressive Agents/pharmacology;
Hydrogen Peroxide/*pharmacology;
Humans;
*Gene Expression Regulation, Neoplastic;
Cyclosporine/pharmacology;
Cell Line, Tumor;
Astrocytes/*metabolism;
*Apoptosis;
Anoxia;
Allergy and Immunology
- From:Yonsei Medical Journal
2006;47(4):551-557
- CountryRepublic of Korea
- Language:English
-
Abstract:
The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing ligand (TRAIL) expression by oxidative stress was shown in LN215 cells, an astroglioma cell line. Hydrogen peroxide (H2O2) treatment increased TRAIL expression in LN215 cells and H2O2-induced TRAIL augmented apoptosis in Peer cells, a cell line sensitive to TRAIL- mediated cell death. Our findings suggest that the upregulation of TRAIL in astroglial cells may abrogate immune cell effector functions.
