Thyroid Transcription Factor-1 (TTF-1) Expression in Human Lung Carcinomas: Its Prognostic Implication and Relationship with Expressions of p53 and Ki-67 Proteins.
10.3346/jkms.2003.18.4.494
- Author:
Na Hye MYONG
1
Author Information
1. Department of Pathology, Dankook University College of Medicine, Cheonan, Korea. myongnh@hanmail.net
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Transcription Factors;
Thyroid Transcription factor-1 (TTF-1) Expression;
Human;
Lung Neoplasm;
Ki-67 antigen;
Protein p53;
Pathogenesis
- MeSH:
Adenocarcinoma/diagnosis/metabolism;
Adult;
Aged;
Carcinoma, Non-Small-Cell Lung/diagnosis/*metabolism/mortality;
Carcinoma, Small Cell/diagnosis/*metabolism/mortality;
Cell Division;
Cell Line, Tumor;
Cell Lineage;
Female;
Human;
Immunohistochemistry;
Ki-67 Antigen/*biosynthesis;
Lung Neoplasms/diagnosis/*metabolism/mortality;
Male;
Middle Aged;
Nuclear Proteins/*biosynthesis;
Prognosis;
Protein p53/*biosynthesis;
Sensitivity and Specificity;
Time Factors;
Transcription Factors/*biosynthesis;
Transcription, Genetic;
Tumor Markers, Biological
- From:Journal of Korean Medical Science
2003;18(4):494-500
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was aimed to evaluate the prevalence and prognostic implication of thyroid transcription factor-1 (TTF-1) immunoreactivity in 81 human lung carcinomas, including 65 cases of non-small cell lung carcinoma (NSCLC) and 16 cases of small cell lung carcinoma (SCLC); and also to investigate its relationship with the cell proliferation and regulation by immunostaining of Ki-67 and p53 proteins, respectively. The immunohistochemical staining for TTF-1(clone 8G7G3/1) was performed and several clinicopathologic variables and the follow-up data were obtained. The immuno-staining results for TTF-1 were semiquantitatively interpreted as negative and positive. Of NSCLCs, TTF-1 is highly expressed in adenocarcinomas (76%), whereas squamous cell carcinomas revealed no immunoreactivity (0%). SCLCs showed strong TTF-1 expression (88%). In NSCLC, TTF-1 expression was inversely correlated with Ki-67 proliferative activity and independent of p53 overexpression. TTF-1(+) group tended to show better survival than TTF-1(-) group in NSCLC. Conclusively, these observations suggest that TTF-1 is a sensitive and specific diagnostic marker for pulmonary adenocarcinomas and SCLCs; that TTF-1 might have a good prognostic implication based on its inverse correlation with Ki-67 proliferative activity and tendency for better survival in NSCLC; that this cell lineage marker may play a role in the molecular pathogenesis of lung cancers at the level of transcription.
