A Case of Metastatic Pulmonary Calcification in Primary Hyperparathyroidism.
- Author:
Kwang Eun LEE
1
;
Hae Jin KIM
;
Si Hoon LEE
;
Sang Woon BAE
;
Eun Seok KANG
;
Hae Won CHUNG
;
Hye Sun SEO
;
Dae Jung KIM
;
Sang Soo CHUNG
;
Sun Jung KIM
;
Young Duk SONG
;
Sung Kil LIM
Author Information
1. Department of Internal Medicine, Yonsei University, College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Metastatic pulmonary calcification;
Primary hyperparathyroidism
- MeSH:
Calcium;
Female;
Follow-Up Studies;
Humans;
Hypercalcemia;
Hyperparathyroidism;
Hyperparathyroidism, Primary*;
Kidney Failure, Chronic;
Lung;
Middle Aged;
Multiple Myeloma;
Parathyroid Hormone;
Parathyroid Neoplasms;
Phosphorus;
Plasma;
Radionuclide Imaging;
Technetium Tc 99m Medronate;
Thyroid Gland;
Vitamin D
- From:Journal of Korean Society of Endocrinology
2002;17(4):583-588
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Metastatic calcification is the deposition of calcium, in previously normal tissue, as a result of elevated plasma calcium and phosphorus product levels and has been reported in patients with parathyroid adenoma, parathyroid carcinoma, hyperparathyroidism due to chronic renal failure, vitamin D intoxication, and osteolytic bone tumors, such as multiple myelomas. The lungs are the most common site of metastatic calcification. We have experienced metastatic pulmonary calcification in a case of primary hyperparathyroidism. A 55-year old woman was admitted due to general weakness. From the laboratory evaluation, hypercalcemia and excess production of parathyroid hormone (PTH) were noted. technetium-99m-labelled sestamibi scintigraphy indicated an intense uptake in the lower pole area of the left thyroid gland, suggestive of a parathyroid adenoma. A technetium-99m phosphate (99mTc-MDP) bone scan showed increased uptakes in both lungs. A parathyroid lobectomy was performed, and primary hyperparathyroidism, due to a parathyroid adenoma, was finally diagnosed. A follow-up 99mTc-MDP bone scan showed the disappearance of the metastatic pulmonary calcification, with the clinical symptoms and biochemical parameters normalizing after 6 months.
