RET Fusion Genes in Korean Non-Small Cell Lung Cancer.
10.3346/jkms.2013.28.10.1555
- Author:
Seung Soo YOO
1
;
Guang JIN
;
Hye Jin JUNG
;
Mi Jeong HONG
;
Jin Eun CHOI
;
Hyo Sung JEON
;
Shin Yup LEE
;
Jeong Ok LIM
;
Jae Yong PARK
Author Information
1. Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. jaeyong@knu.ac.kr
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't
- Keywords:
RET Fusion;
KIF5B;
CCDC6;
Carcinoma, Non-Small-Cell Lung;
Korean
- MeSH:
Asian Continental Ancestry Group/*genetics;
Carcinoma, Non-Small-Cell Lung/epidemiology/*genetics/surgery;
Cytoskeletal Proteins/genetics;
Female;
Humans;
Kinesin/genetics;
Lung Neoplasms/epidemiology/*genetics/surgery;
Middle Aged;
Oncogene Proteins, Fusion/*genetics;
Proto-Oncogene Proteins c-ret/*genetics;
Republic of Korea/epidemiology;
Sequence Analysis, DNA
- From:Journal of Korean Medical Science
2013;28(10):1555-1558
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we examined the RET fusion genes in 156 surgically resected NSCLCs using a reverse transcriptase polymerase chain reaction. Two KIF5B-RET fusions and one CCDC6-RET fusion were identified. All three patients were females and never smokers with adenocarcinomas. RET fusion genes were mutually exclusive from EGFR, KRAS mutations and EML4-ALK fusion. RET fusion genes occur 1.9% (3 of 156) of surgically treated NSCLC patients in Koreans.
