Secondary Mania and Frontal-Subcortical Circuit.
- Author:
Hee Jeong JEONG
1
;
Young Min LEE
Author Information
1. Department of Psychiatry, Pusan National University Hospital, Busan, Korea. psyleekr@naver.com
- Publication Type:Review
- Keywords:
Bipolar disorder;
Late onset;
Frontal-subcortical circuits
- MeSH:
Apathy;
Bipolar Disorder*;
Executive Function;
Impulsive Behavior;
Neurobehavioral Manifestations
- From:Journal of Korean Geriatric Psychiatry
2013;17(2):56-60
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Secondary mania is closely linked to neurocircuitry defects. Frontal-subcortical circuits, in particular, play a major role in the affective, motor and cognitive symptoms of secondary mania. In this paper, we present the three main frontal-subcortical circuits : the dorsolateral prefrontal circuit, which mediates executive functions (i.e., the organization of information to facilitate a response) ; the anterior cingulate circuit, which is involved in motivated behavior ; the orbitofrontal circuit, which has medial (i.e., integration of visceral-amygdalar functions with the internal state of the organism) and lateral divisions (i.e., integration of limbic and emotional information into contextually appropriate behavioral responses). Impaired executive functions, apathy, disinhibition and impulsivity are hallmarks of frontal-subcortical circuit dysfunction. The various neuropsychiatric manifestations of secondary mania may result from disturbances that have a direct or indirect impact on the integrity or functioning of these loops.
