The Frequencies of HLA Alleles in Bipolar Disorder.
- Author:
Taeyoun JUN
1
Author Information
1. Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Bipolar disorder;
HLA
- MeSH:
Alleles*;
Bipolar Disorder*;
Genetic Markers;
HLA-B51 Antigen;
Humans
- From:Journal of Korean Neuropsychiatric Association
2000;39(1):219-228
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: To evaluate the potential of HLA as a candidate gene for the genetic marker of bipolar disorder, we carried out the association study between allelic frequency of HLA and bipolar disorder. METHODS: HLA class I and class II allelic frequencies were assessed in 87 Korean bipolar disorder patients and were compared with the data from 206 normal controls. HLA class I typing was performed with microlymphocytotoxicity method and HLA class II(DQB1 and DRB1) genotyping with reverse dot hybridization. The allelic frequencies were analyzed using x2 test with two-tailed Fisher's exact test. RESULTS: Bipolar disorder patients showed increased allelic frequencies of HLA-A29 and B54 and decreased allelic frequencies of HLA-B51 and DRB1*02 compared to normal controls. CONCLUSION: These results suggest the possibility of association between HLA gene and bipolar disorder. To clarify the genetic influences of HLA on bipolar disorder, further systematic studies should be conducted.
