A Case of Lewis-Sumner Syndrome Showing Dramatic Improvement after Plasma Exchange.
10.3346/jkms.2010.25.7.1101
- Author:
Young Eun PARK
1
;
Ji Won YOOK
;
Dae Seong KIM
Author Information
1. Department of Neurology, Pusan National University School of Medicine, Busan, Korea. dskim@pusan.ac.kr
- Publication Type:Case Report ; Research Support, Non-U.S. Gov't
- Keywords:
Lewis-Sumner Syndrome;
Plasma Exchange;
Conduction Block;
Nerve Pathology;
Cranial Nerve Diseases
- MeSH:
Adrenal Cortex Hormones/therapeutic use;
Adult;
Demyelinating Diseases/*diagnosis/pathology/physiopathology/*therapy;
Humans;
Immunoglobulins, Intravenous/therapeutic use;
Male;
Neural Conduction/physiology;
Peripheral Nerves/pathology/physiopathology;
*Plasma Exchange;
Syndrome;
Treatment Outcome
- From:Journal of Korean Medical Science
2010;25(7):1101-1104
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a patient with Lewis-Sumner syndrome (LSS) who showed an improvement only with plasma exchange (PE). The patient, 32-yr old man, had progressive multifocal motor-sensory deficits with persistent, multiple conduction blocks and marked slowing of NCVs. Nerve pathology supported a diagnosis of demyelinating neuropathy by revealing marked loss of myelinated fibers with inter- and intrafascicular variation. Although the patient was refractory to treatment with corticosteroid and intravenous immunoglobulin, PE produced a dramatic improvement. Our experience strongly proposes that PE should be tried for refractory LSS.
