Biologigic membrane for guided bone regeneration.
- Author:
Jong Rak HONG
1
;
Nara KANG
;
Pill Hoon CHOUNG
Author Information
1. Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University.
- Publication Type:Original Article
- Keywords:
Freeze-dried cartilage;
Guided bone regeneration
- MeSH:
Adult;
Animals;
Bone Regeneration*;
Cartilage;
Drug Delivery Systems;
Humans;
Mandible;
Membranes*;
Rats;
Rats, Sprague-Dawley;
Transplants
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2004;30(1):17-24
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this study was to evaluate the stability and efficacy of biologic membrane made of freeze-dried cartilage as a barrier to facilitate guided bone regeneration in experimental non-healing bone defects in the rat mandible. Nine adult Sprague-Dawley rats (400-500g) were used in experiment. 5.0mm in diameter were created on the mandibular angle area by means of slow-speed trephine drill. In microscopic examination, dynamic immature bone forming at 2 weeks and its calcification at 4 weeks were observed. The membrane made of lyophilized cartilage taken from human costal cartilage seems to be very effective for guided bone regeneration as a biologic membrane and the scaffold for attachment of cells or local drug delivery system of growth factor, which may meet the ideal requirement of a barrier membrane and graft materials.
